Mass spectrometry imaging msi provides spatial information on parent drug drug metabolites and or endogenous compounds eg identification of biomarkers on whole body or tissue slices without the need for any radiolabeling 13 msi has been around for more than two decades 14 but its popularity in many fields including adme related analyses 15 has exponentially grown lately due to ever increasing hrms mainly sensitivity and ms resolution and laser technology mainly spatial . Mass spectrometry in drug metabolism and pharmacokinetics is a valuable and interesting resource for a broad readership including scientists starting to work in dmpk as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of ms a wealth of information is provided and all of the contributing authors have done an excellent job in explaining and outlining particular aspects of ms based tools in dmpk the book is highly recommended . Mass spectrometry in drug metabolism and pharmacokinetics ramanathan ragu isbn 9780471751588 kostenloser versand fur alle bucher mit versand und verkauf duch amazon. This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies with contributions by professionals from the pharmaceutical industry this book begins with a review of current mass spectrometry techniques and applications followed by discussions of various methods for using ms in drug metabolism studies and pharmacokinetics highlighting the critical importance of adme studies for understanding how a drug is absorbed distributed metabolized and excreted
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