To cater to the need analysis of protein interaction networks pins has gained importance as one of the promising strategies the present review aims to discuss various computational approaches to analyse the pins in context to infectious diseases topology and modularity analysis of the network with their biological relevance and the scenario till date about host pathogen and intra pathogenic protein interaction studies were delineated this would provide useful insights to the research . Protein interaction networks computational analysis the analysis of protein protein interactions is fundamental to the understanding of cellular organization processes and functions pro teins seldom act as single isolated species rather proteins involved in the same cellular processes often interact with each other. The analysis of protein protein interactions is fundamental to the understanding of cellular organization processes and functions recent large scale investigations of protein protein interactions using such techniques as two hybrid systems mass spectrometry and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein . These protein protein interactions ppi lead to a mosaic mesh or network of interactions commonly known as protein interaction networks pins analyses of such pins are increasingly serving as the non conventional approach to understand the complexity of infectious diseases however the augmentation of the pins created from high throughput experimental and or computational data has necessitated effective analytical techniques for those networks to be used to unravel the molecular
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